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Monday, August 22, 2016

Natural Aldosterone Lowering Supplements (Supplements to Lower/Decrease Aldosterone)


Below is Wiki's overview of Aldosterone. A Summary I mostly agree with.
Aldosterone is a steroid hormone, "the main mineralocorticoid hormone",[1]:50 produced by the outer section (zona glomerulosa) of the adrenal cortex in the adrenal gland.[2][3] It plays a central role in the regulation of the plasma sodium (Na+), the extracellularpotassium (K+) and arterial blood pressure. It does so mainly by acting on the distal tubules and collecting ducts of the nephron, increasing reabsorption and excretion of ions out of and into the tubular fluids of the kidney, to cause the conservation of sodium, secretion of potassium, and thereby indirectly influencing water retention or loss, and influencing blood pressure and blood volume.[4]When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and renal disease.[3] Aldosterone has exactly the opposite function of the atrial natriuretic hormone secreted by the heart.[4]
Aldosterone is part of the renin–angiotensin system. It has a plasma half-life of under 20 minutes.[5] Drugs that interfere with the secretion or action of aldosterone are in use as antihypertensives, like lisinopril, which lowers blood pressure by blocking the angiotensin-converting enzyme (ACE), leading to lower aldosterone secretion. The net effect of these drugs is to reduce sodium and water retention but increase retention of potassium. Another example is spironolactone, a potassium-sparing diuretic of the steroidalspirolactone group, which decreases blood pressure by releasing fluid from the body while retaining potassium.
Aldosterone was first isolated by Simpson and Tait in 1953.[6]

But there are some things that perhaps are more important than these facts. Like the fact that we can use natural medications / herbs to lower aldosterone, and also that aldosterone is involved with muscle tone [7] [8] and the appearance of muscle definition because of it's role in sodium distribution through the body [9]. High amounts of Aldosterone hide our hard-earned gains by causing sodium retention, and high blood pressure at higher amounts, creating a state similar to adrenaline-dominance, except through a much nastier pathway [10] [11].

Therefore, lowering aldosterone has utility in bodybuilding and especially, 'cutting', aka getting shredded, getting to low body fat and low water retention.

So let's do this.

1.) As with ACTH, Ginkgo Biloba extract remains one of the best anti-stress supplements that also reduces aldosterone significantly [12]. Ginkgo also acts to cause vasodilation and has a slight diuretic effect through other mechanisms as well [13] [14]. This all leads to muscle growth and improved blood pressure. NOTE:  Ginkgo reduces aldosterone by inhibiting the Angiotensin-Converting enzyme which normally acts to help produce Aldosterone [15].

2.) Magnesium again, in normal healthy subjects even, Magnesium reduces the blood aldosterone concentration [16]. It also protects the heart after a heart attack [17], and helps prevent heart attacks [18]

3.) Hibiscus Sabdariffa extract is one of the most powerful, human-studied natural aldosterone inhibitors available. See this study here on Nigerians with HBP.

When No Obstacles Remain, There I Become.






It could never have been said, or written another way better. The deadly truth, is also a healing truth. The reality is what others have been starved from. My tune is that reality. The reality that their punchline has been on a road to expiring for a long time. The reality that my goals are the ones that have been kept, fought for, and have been set back, and then made to re-equip, so that for a time they looked abandoned, so that for a time, my goals seemed far away. The truth? 

My goals can't be stopped, I realized that when I saw how quickly some would concede. I saw that my future was an awakening, that one idea standing on top of the highest mountain. Seeing everything that nobody else saw, or would dare to accept. Those are the reasons why I am able to do what I do. I don't need or want the foolishness of others to be my reality, and if I choose to emulate it, then I do it out of choice. For no other reason would I appear differently, just as my perception is but a choice. I choose to perceive in the way I do. I choose the battles that I keep - and I win them, always.

Then it dawned on me, that the now arisen enemies, who have fought so long to maintain their ignorance under the guise of intelligence, life, and health - would now have to concede, or be dropped to the ground. My instincts understand the future, I understand the future. As with before, my predictions hold true, and so shall they now.  

The former have passed away into an abyss, they no longer have the grasp they once had. They are trying to hold on, but it is in blindness that they do so, and they are far too arrogant to hold on with meaning, so they fall. I will let them. Not because I hate them, or what they stand for, but because I have a mission. I must be at their place, because destiny has called me. The future of my dreams is not a dream, nor is meant to be. It is my calling, my one truth. That truth that others have failed to understand. This is my belief, my power and my salvation. A strength never seen by the unobserving eye, nor even my own - at least to the extent into which, when revealed, it takes its own form. Understanding the reasons for both good and evil, understanding the true comparison, understanding human momentum. These are my realities.

I see now that all through my life, people have tried to hit me hard, and antagonize my dreams, they have even set me back, but the one thing that stops them, that CHOKES them, is the fact that no matter what I keep going, then putting on the armor that THEY gave me, the immunity to their hits is what makes me strong. It's what fires up my soul for more courage, the fact that every one of them just had to paralyzed, had to be defeated because I chose to use what I was given. They lost at that moment. Because they were overwhelmed, all of my enemies had lost their grasp, just as the current ones do. Because they can not understand the type of resilience I possess, maybe its inhuman. Maybe it's divine, a power from not this world. Or maybe, it is simply a man who has not forgotten what he has learned, and has taken things for what they are - who has absorbed a path to greatness because of his acceptance, and ultimately the utilization of everything that has been his past. That is why I succeed - that is why others fall. They do not hold things because they have been taught it is weakness to do so. 

In reality, this could be only my method no? A method that only I and a few others have truly perfected, because with great mental stamina comes the ability to reach for all dreams in a no questions asked manner. Instead of relying on each of my strengths individually, I see them all as one. I may train each of them differently, but ultimately I see them all as one. Ultimately, I see them as unity, and completion, as one sword - myself. One durable, one enduring, one made more magnificent as each day completes itself. Because now, there is nothing stopping it, as with before, and with this small amount of time I have given myself, to complete the final task - will reveal my final self. 

The sum of my past + years of growth. Years of knowledge gained. Years of self-progress. Years of understanding gained in a short time. Years understanding myself. Years that have brought me to this place. Years that have sought to understand even themselves, and have for a time, became inconclusive, until it all made sense. Then those considerations I've made and no one else has, are the final tools to my strongest steps. My boldest reality to be shone on the world. The absolute completion of what I have longed to obtain. 

It's mine and no one elses, and while others fight to keep their power alive, I will fight relentlessly even when there is no fight in sight, because I know power is seen, and envied. I know how many thiefs there are, both of the mind and soul, and of possessions. So I will take unprecedented steps, and creative, nothing short of innovative precautions, so dissolve threats before they become threats. So that my reality, is a King's reality, an undefeated one. One that the strongest armies of men will not be able to defeat. Because they do not understand all sides of the story of life, and they haven't perfected the various perceptions I've created. It's an illusion to them, but it's my reality. My empire, my being, my world. 

Sunday, August 21, 2016

Natural ACTH Lowering Supplements (Supplements to Lower/Decrease ACTH) (Adrenocorticotropic-Hormone-Antagonists/Blockers)

ACTH, also known as adrenocorticotropic hormone, is a polypeptide ''tropic hormone'' that is produced and secreted by the anterior pituitary gland, in mammals and humans [1]. It's main function is to increase cortisol release from the adrenal cortex and to help maintain equilibrium during Stress [2] [3]. ACTH plays a large role in body temperature [4], mood [5], metabolism [6], resistance to stress [7] [8] [9] and as well, the uptake and proper usage of electrolytes in the body [10]. It also regulates bone mass, low concentrations of ACTH may oppose osteoblast differentiation and high amounts may have anabolic / growth-promoting effects on bone [11]. ACTH is heavily involved with human fertility as well [12] [13] [14].

Among all of these facts, leads one question. What is the purpose of lowering ACTH? 

Well since ACTH increases Cortisol, those with hypercortisolemia (cortisol excess), and the resulting high blood pressure and / or fat gain in problem areas (especially face, trunk/abdomen, hips) may seek to 'hit the problem at the root', which is lowering ACTH in order to get cortisol under control. A valid strategy indeed, but the idea that we should just lower ACTH is also often misread, what we want to do is actually fine-tune the Adrenal Cortex and Adrenal gland so that we are not missing out on the benefits of the lower level glucocorticoids. 

To reduce ACTH and fine-tune the adrenal hormones, we can use three specific supplements.
NOTE: The box next to the name of the supplement with the exclamation mark leads to the primary source/citation regarding the herb or supplements interaction with ACTH.


1.) Ginkgo Biloba Extract [!] {You can buy it HERE}
Proven in humans to reduce stress-induced rise in blood pressure and cortisol/ACTH secretion. It is used by many athletes today, as well as those with prior atherosclerosis and in those with memory problems [Reference].


*Ginkgo Supplements should be taken at 120 MG twice a day for this purpose.*


2.) Magnesium [!] : Nature's Anti-Stress mineral, and well-known for improving sleep and muscle strength. {It can be bought HERE}


3.) Ashwagandha Extract + Phosphatidylserine [!] [!] [!] - Perhaps the most effective combo, these supplements have been used for years to alleviate stress and to improve mental endurance / resilience. Highly recommended, and especially for younger people.


You can buy a powerful Phosphatidylserine supplement --> HERE.

*Phosphatidylserine should be supplemented at 400 MG / per day as shown in the studies. Ashwagandha, simply follow the directions on the bottle*.

Friday, August 19, 2016

Supplements to Restore Love Fantasies (Supplements to Increase Feelings of Love and Dreams of Finding It)





Perhaps this article is a little 'girly' in comparison to the previous articles and theme of this site. Indeed, we are creating many offshoots of 'Area-1255' with our other team members and their recruits. With this article though, sets a new precedent, to encourage humans to be humans, and for those who take a more serene look at life, and those who see our design as humans by the quote below.



Now, the idea of increasing love is not a new one for existing couples, but this article is about elevating the desire & aspirations of one person who feels they don't feel enough. It's about restoring love fantasies by directly manipulating the neurotransmitter systems in our brain to a more youthful state. It's about priming the emotional circuits of our brain to see human emotion itself as a passion and to reignite an almost childish view (a broad one at that) of unique aspirations. It's about specific aspects of euphoria and quality of life resulting from our emotions being reinvigorated...

We need to focus on the few chemicals that are associated with love, and the limbic system associated with creativity and fantasies.

1.) PEA : The first strategy to increase love fantasies is to inhibit the breakdown of the love chemical PEA, or Phenylethylamine. We do that by blocking an enzyme called MAO-B. You can try something like Selegiline [1], or simply take a Garlic Supplement as well as Turmeric capsules daily [2] [3].

2.) Oxytocin : We need to lay the groundwork, raising PEA only helps when the natural framework for emotions and love in specific, is enriched with the peptide hormone Oxytocin. To increase oxytocin, we need to ensure its availability and release in the human brain, to do that, we need enough histamine and dopamine. Supplement with L-Histidine daily at 1-3 grams per day [4] [5].

3.) Dopamine : Dopamine must be made available to permit love fantasies, it is absolutely crucial for the feeling of love, attraction, trust and passion. Dopamine can be increased by taking something like Mucuna Pruriens Extract daily [6].

4.) GABA : GABA levels can not be too high to feel love, as they suppress the emotional circuitry of the brain when they are consistently elevated. Don't over use or use GABA supplements when not completely necessary, avoid benzodiazepines at all costs.

5.) 5-HT7 Serotonin Receptors : Suppress all aspects of love and emotions in general, including the cognitive aspects, blocking this receptor can ensure that serotonin can not suppress the feelings of love and emotion. Dopamine autoreceptors interact with this receptor, so blocking both by a very very low dose of Amisulpride (12.5 MG) can be perfect for rejuvenating the feelings of love and the aspirations of such. You could also simply use a natural 5-HT antagonist like Shilajit which may do the trick just as well [7] [8] [9].


***CITATIONS/SOURCES***
J Neuropsychiatry Clin Neurosci. 1995 Winter;7(1):6-14.

Biol Psychol. 2010 Jul;84(3):394-421. doi: 10.1016/j.biopsycho.2010.03.010. Epub 2010 Apr 4.

Emotion. 2011 Dec;11(6):1314-21. doi: 10.1037/a0024090.

Indian J Endocrinol Metab. 2011 Sep; 15(Suppl3): S156–S161.
doi:  10.4103/2230-8210.84851

EMBO Rep. 2013 Jan; 14(1): 12–16.
Published online 2012 Nov 27. doi:  10.1038/embor.2012.191
PMCID: PMC3537144
Science and Society

Psychoneuroendocrinology. Author manuscript; available in PMC 2014 Feb 27.
Published in final edited form as:
Psychoneuroendocrinology. 2012 Aug; 37(8): 1277–1285.
Published online 2012 Jan 26. doi:  10.1016/j.psyneuen.2011.12.021

Endocrinology. 1999 Mar;140(3):1158-64.

Eur J Endocrinol. 1998 Aug;139(2):238-43.

Ann N Y Acad Sci. 1999;897:182-91.

Psychiatry Res. 2014 Sep 30;223(3):253-60. doi: 10.1016/j.pscychresns.2014.05.016. Epub 2014 Jun 5.

Front Hum Neurosci. 2015; 9: 191.
Published online 2015 Apr 9. doi:  10.3389/fnhum.2015.00191

Psychopharmacology (Berl). Author manuscript; available in PMC 2010 Oct 1.
Published in final edited form as:
Psychopharmacology (Berl). 2009 Oct; 206(3): 345–354.
Published online 2009 Aug 1. doi:  10.1007/s00213-009-1626-0

Saturday, August 13, 2016

Supplements to Wake Up Earlier! (Supplements to Wake Up Refreshed & Ready to Go)



Let's face it, one of the best feelings in the world is waking up refreshed and more than ready to tackle the world. It's not sleeping in, wanting more sleep, wondering if you should go back to sleep - it's just the excitement of getting right up and jumping out of bed in energy, and fulfillment. Remember the days as a child, when you were up at all hours, constantly nagging for your next thrill? Remember the energy of waking up before everyone else in your house? You carrying extra enthusiasm while the others still have to sleep for 4 more hours to feel 'normal'?

Even if you weren't that person before, you can become that person now.

Brain research has come A LONG way in the past few years, we now know that our circadian rhythm, and specific regions of the brain called the Suprachiasmatic nucleus & the Pineal gland are key in determining our sleep cycle, length of sleep, quality of sleep and waking time [1] [2]. We know that histamine neurons shut down completely when we are sleeping [3] [4] [5].  We also know that noradrenergic neurons promote wakefulness by their input from histaminergic neurons [6]. In short, that means that histamine can stimulate noradrenaline to promote wakefulness [7] [8]. Additionally, studies show that the norepinephrine transporter, which transports norepinephrine (a type of adrenaline) out of the active zones of the brain, is heavily connected to wakefulness and mood [9]

Norepinephrine Transporters (NET) thus are a major target in human psychological state and disease research [10] [11]. Given the extensive research on noradrenaline & histamine in regards to sleep and waking cycles, it seems reasonable that one could target them to promote early awakening. 

However, first we need to focus on the quality of sleep.

In order to improve our quality of sleep, we need to know what increases our quality of sleep, and what dietary habits could be impairing it.

Research shows that eating certain types of food before bed, like spicy foods, may make it difficult or uncomfortable to sleep [12], however they may also increase metabolism during sleep [13] and promote early awakening [14].

Excessive exercise within 3-hours of sleep is also likely to interrupt the sleep cycle and make it hard to get to sleep in the first place [15] [16]. Make it a point to finish your exercise routine well before the time of night or day when you go to sleep.

Supplementing with low (5-10 MG), but not high dosages ( >15 MG) of melatonin may promote quality sleep and early awakening [17] [18]. No risk of dependence or adverse effects is noted with long-term melatonin trials and reports [19] [20]

Now let's work on the norepinephrine angle. Supplements that may mildly inhibit the norepinephrine transporter, enough to increase wakefulness but not enough to subdue the onset of sleep, would include.

1.) Ginkgo Biloba Extract [21] [22] [23]. {Buy it Here}
2.) Kava Kava Extract [24] [25] {Buy it Here}
3.) Psoralea corylifolia [26] [27]. {Buy it Here}

There's also a pharmaceutical drug which is approved in many countries for Depression called Reboxetine (brand name Edronax). I would recommend trying the natural solutions first, but if you do not find the results you are looking for with them, you could try a low-therapeutic dose of Reboxetine (1-2mg) in the morning time only, once per day. It can be bought at.


So those would be my recommendations above. Use an norepinephrine-reuptake inhibitor that is mild, do not drink Coffee past 6 PM or according to your sleep schedule, and ration it when at all possible. Preferably do not eat spicy food before bed, but if it does not impair your ability to get to sleep, then by all means it has been shown to increase early awakening, when done consistently.

Keep track of your exercise schedule, and do not over-train. Take low dose melatonin at night (between 5 - 10 mg / every night). These methods are all great and proven to work, not only by science but also separate reports. 

See these forum entries for more encouragement.

  1. Melatonin and Early Morning Wakeup (Mothering.com Forum)
  2. Early Awakenings Discussion @Longecity Forum.
  3. Reboxetine is cool stuff @Longecity Forum.





Saturday, August 6, 2016

PES Select Protein Snickerdoodle Flavor REVIEW (Physique Enhancing Science Select Protein Review)


This is my first review on a PES Protein product, I've tried other P.E.S products, like Anabeta Elite and Erase Pro, but never their protein. Upon my first drink (with whole milk) all I can say is ''Wow, this stuff is good". That's even an understatement, it tastes better than Syntha-6 and better than Optimum Nutrition's Whey. Some have claimed it is too sweet, I don't feel it is. The effects? Can't really say it 'feels' that much different than other protein, but I did notice a more 'content' feeling after a workout and there was a stronger muscle hardening effect. I can't attribute that entirely to the protein though, but I did recover a little quicker on this - and I wasn't taking ANY other supplements during my go with it, except a MultiVitamin. So there might be something to their Casein/Whey blend, and it seems they also add Leucine-peptides, which could contribute to the anabolic effect.


I ordered it from Bodybuilding.com, but you could also order it on the P.E.S website or on Amazon {http://ow.ly/DNnR302ZPbU}.



Area-1255's Rating of P.E.S Select Protein Snickerdoodle is 5/5.

TASTE
  • Absolutely delicious. Nothing like it, but only if you use 2% or Whole milk with it. It tastes better than any milkshake if you mix it right. In terms of taste, it is superior to other brands like Syntha-6 and O.N. They are close, though. 
  • I haven't tried the other flavors yet, but every time I drank the Snickerdoodle Protein, it was the original taste-euphoria all over again. Amazing, delectable taste. Not sure how else describe it.
It mixes very well, including in a regular cup and simply using a spoon to mix it - works well, but is preferable in a blender or shaker cup.


EFFECTS 
  • Seemed to speed up recovery, muscles seemed to gain a quicker dense feeling.
  • No bloating and not overly filling.
  • Seemed to boost energy and motivation.
DRINKABILITY/EFFECT ON APPETITE
  • It is not overly filling. After repeat drinks, it still mixes fine and tastes delicious. It isn't really 'heavy' but then again I only drank 3-4 shakes a day. 
  • It does not seem to have a noticeable effect on appetite, nor should it.
PRICE
  • 29.99$ at Bodybuilding.com is not bad. That gave roughly 30 servings.
  • Considering that it can be considered a bit steep, but considering the taste and lack of negative digestive effect - I'd say its a pretty fair price.
  • I'm not sure about the other flavors but I reckon they probably are similar in taste. 



Bodybuilding Store Page for PES Select Snickerdoodle.
~Other PES Product Reviews by Area-1255~
                                                                   

Friday, August 5, 2016

Bench Press Increasing Supplements (Supplements to Increase Your Bench / Increase Bench Press Supplements)


Last month I discussed a post somebody made regarding his experience with a particular supplement (RS Transaderm). It was @ that point that I also had reviewed multiple review posts on Anabolicminds.com forum. Reviews on the same product that spoke volumes. Then, we had one of our own (Damage) who trialed the product (see review here), and to his surprise, he experienced the same benefits the other posts did (and he's an experienced logger, but more of a debunker). It was at that point I knew we were on to something good...


...But without research it means nothing. 

Fortunately, there is some I was able to find. Most fitting for the current circumstance, and definitely enlightening. You see, there are really only 5 real supplements that have actually been definitively PROVEN to increase the bench press, and to increase relative strength in general, in such a fashion to where it would be independent of any other variable, and thus absolutely related to the supplement at hand. 

I'm going to discuss these supplements.

1.) DHEA is nothing less than remarkable in that regard, study after study after Study shows that it reliably increases strength on the Bench press, and in general [1] [2] [3]. Pregnenolone enhances mood, and strength independently of each other [4], but the only exception, is THESE TWO Neurosteroids, MUST BE APPLIED TRANSDERMALLY for their effect to be Counted. RS Transaderm is the only product on the entire supplement market that effectively delivers these hormones through the skin to the blood, and because it contains an anti-estrogen Phytocomplex as well as a patented bioavailability enhancing agent, it is simply the strongest of any product in doing so. It can be bought from the store here

RS Transaderm Store Link

2.) PhytoSERMs 347X is another product that really delivers in the area of bench press, not only does it have hundreds of good reviews, but the science is solid.
It contains Fadogia Agrestis, which is a powerful Testosterone-booster shown to increase strength dramatically. It also contains several other herbs which have, independently been shown to increase strength in both Primates and humans.

3.) The next thing I'm going to talk about, technically isn't a supplement. It's an anabolic steroidal compound but with special emphasis on being NON-TOXIC and being available as a tablet Versus an injection. It's very safe, even for noobs, and is also considered a 'brain-hack' because of its ability to skyrocket confidence & aggression [5] [6]. The product/compounds name is "Proviron". It's available for only 24$ not including shipping, @Napsgear {http://ow.ly/e2EU302Yoom} - and has tons of non-sponsored positive reviews.

4.) The next big strength breakthrough is actually one that's been around for a while; Creatine. There's no arguing with it, because virtually everyone who has supplemented with it has been pleased. It also has a massive wealth of research behind it [7] [8] [9].

5.) And the last on this list? Tongkat Ali. The worlds signature test-booster, shown time after time to consistently increase Free Testosterone (FTT) and Total Testosterone (TT) [10] [11] [12]. That's not enough? Check out the multitudes of reviews on multiple forums.