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Tuesday, November 29, 2016

The Definite Role of Serotonin Excess & Deficiency in Psychiatric Disorders

Serotonin has consistently played a large role in mental illness [1] [2] [3]. However, the role that serotonin plays has been disputed, and research has shown that both excessive levels and deficient levels can contribute to onset of mental illness [4] [5].

The severity of certain disorders such as Generalized Anxiety and Obsessive-Compulsive-Disorder is also directly related to Serotonin status and levels in healthy individuals and Physically ill individuals [6] [7] [8] [9].

Personality traits are also influenced by serotonin levels, and increased serotonin tends to lead to callousness in individuals with Antisocial personality disorder.


CONDITIONS THAT ARE RELATED TO ELEVATED SEROTONIN LEVELS INCLUDE...
Elevated = Moderately High


DISPUTE  : Why are SSRI's used to treat OCD/Anxiety then?

ANSWER : Simply because, researchers haven't really discovered all of the actions of SSRI's until now, and ''therapeutic response'' often correlates with SSRI-induced downregulation of serotonin receptors and often, to increases in allopregnenolone levels which then enhance endogenous (naturally produced) GABA levels.

Downregulation means that the receptors have decreased in number within one or more regions of the brain.

Therefore, and due to Selective-Serotonin-Reuptake-Inhibitor (SSRI) induced desensitization of other receptors, besides the ones it downregulates, the net (total, summed) effect of SSRI's is actually a long-term anti-serotonin effect on multiple brain regions and an effective 'redirection' or redistribution of the serotonin levels that remain enhanced.


|SOURCES|



Effect of long-term administration of antidepressant treatments on serotonin release in brain regions involved in obsessive-compulsive disorder.

5-HT1B Receptors and More General Insights into Serotonin Role in Mental Disorders

Additionally, 5-HT1B (Serotonin-Receptor 1B) function is increased in obsessive-compulsive disorder and decreased in Cocaine-dependence [24] [25].

This outlines the viability of receptor research in understanding and treating these disorders. 

Being that 5-HT(1)B receptors and their function correlate to Serotonin Transporter (SERT) activity [26] [27] [28], and SERT essentially recycles our brains serotonin [29] [30] and removes it from activity, it would make sense that this key receptor would be heavily involved with the pathophysiology of these various mental disorders [31] [32].





https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436296/

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.542.3432&rep=rep1&type=pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418507/

http://s3.amazonaws.com/academia.edu.documents/45595397/539.full.pdf?AWSAccessKeyId=AKIAJ56TQJRTWSMTNPEA&Expires=1480478273&Signature=0f%2F%2Fl76cv958MP97kKROD858NpU%3D&response-content-disposition=inline%3B%20filename%3DFunctional_Interactions_between_5-Hydrox.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576414/

Friday, November 25, 2016

Delineation of Psychopathy, It is A Mind-State, Not Some OtherWorldly Being, Not Some 'Sick' Entity Within A Man

Psychopathy is a crude term applied to many individuals whom display a lack of remorse, a lack of respect for legal repercussions and for the law in general. It also is said that to relish manipulation, is a sign of true evil, and an untrustworthy person stands by deceptive tactics. If Psychopathy is designated by these outlines, then this could apply to more than those diagnosed as 'Psychopaths.

In fact, this criteria (lawlessness, manipulation, lack of remorse) can be applied to borderline personalities, bipolar incidents, methamphetamine induced behavioral alteration, and many other altered mind-states, some of which may not be intentional in nature, such as with delusional states , which in some cases can appear as the above, of course, because the overt dissociation, or apparent delusion overshadows rational thinking, or because the power of these delusions can impact normal emotional processes... but then, if these cases are strong enough to appear one way, and yet be diagnosed as something different, then what is the true determinant of emotional impairment?

More to the point, if such diverse mental disturbances can contribute to interrupted emotional connections, then how sensitive are emotions , human emotions, to disruption, convergence of other processes which block their normal expression, or general decay?

Is it also possible that emotions, are a state-of-mind?
Of course.

Which brings me to the main next point, which will stand as a rupture to stigma, and therefore countering the alienation of whom we call Psychopaths today. Law & Order , Serial Killer Documentaries, Criminal Minds and other TV programs have done a great job at elucidating the mental processes in offending Criminals who fit into what we call Psychopaths, but they also allow us, well, the majority of watchers, to overlook the origin concepts which are necessary to understand the root of Psychopathy and the early elements which , at base, reveal a more subtle, but important reality.

The reality that Psychopathy is a State of Mind.


And that lack of Remorse is not an inhuman phenomenon.

It is a very human one.

Furthermore, because it is often noted that someone who is a 'Psychopath' has the innate ability to dissociate themselves, from the perception of their actions, or from their own emotions, or from the reality of a given situation, it seems that even more so, Psychopathy is truly a mind-state. It is the absorption of crude, often materialistic, and undifferentiatable resilience as the energy and mainstay of ones mind state. Psychopathy is simply put, the state of being a linear minded, action oriented, power-inclined individual. It is the state of acting not on emotion, but of desire.






Best Laptops for Making Instrumentals / MP3's & For Making Movies 2016-2017 (Best Laptops for YouTube Uploading Video Making 2016-2017)






The last in the series of Three, this article will talk about computer technology, graphics drivers, Random Access Memory and multi-tasking ability. It will go over the ability of laptops to run large and sophisticated video editing software and which laptops are ideal for movie editing and YouTube movie making.

Previously we had written...


As with the prerequisites for Game Emulation and 3D-game playing, a solid laptop for Video Editing should have a powerful processor; something like the Intel Core i7 or i5 quad-core processors would work great!


These processors perform especially well at video transcoding, encoding/decoding, transferring, process management, data merging, previewing and display optimization. They are optimal not only in video editing, and music editing, but also in mixed video-music management and for watching the compilations with ease.

Second, a good hard drive and hard drive capacity is absolutely necessary. You need space to put all the accessory files, and parts of the video and music that you will be editing, layering and adding to the final result. You need to be able to do this without lag, and efficiently so that you can correctly go over the result of your editing suite. Therefore, you must have around 500 GB (GigaBytes) at the least.

Third, you need good RAM, and a good graphics card like NVIDIA or AMD. RAM for storing and using data efficiently, as well as the programs and files involved must have a place to put their data, and graphics card for actually moving the content/footage into pixels from coded information.

These 5 laptops are ideal for all forms of media editing, including photos, music and Video editing. These all are well-able to perform these functions and more!

They also are a really good deal...


  1. ASUS K501UW-AB78 15.6-inch Full-HD Gaming Laptop (Intel Core i7, GTX 960M, 8GB DDR4, 512GB SSD) Glacier Grey
  2. Dell Inspiron i5378-7171GRY 13.3 FHD 2-In-1 (7th Generation Intel Core i7, 8GB, 256GB SSD) Microsoft Signature Image
  3. ASUS ROG G751JY-VS71(WX) 17-Inch Gaming Laptop (Intel Core i7, 16GB RAM, Nvidia GeForce GTX 980M, 1 TB HDD, Windows 10)
  4. Apple MacBook MLHE2LL/A 12-Inch Laptop with Retina Display (1.1GHz Dual Core Intel m3, 8GB RAM, 256GB HD, OS X), Gold NEWEST VERSION
  5. Alienware AW17R3-8342SLV 17.3-Inch UHD Laptop (6th Generation Intel Core i7, 16 GB RAM, 1 TB HDD + 256 GB SATA SSD, NVIDIA GeForce GTX 980M,Windows 10 Home), Silver


Best Laptop to edit Music/Beats | Edit Video's | Edit Movies : 2016-2017

Laptop Processor | RAM | Resolution | Size | Price
ASUS Gaming Pro* Intel® i7   | 8GB   | 4k UHD |      15.6″ Under $1000
Dell Inspiron i5378* Intel® i7   | 8GB | 4k UHD |       13.3″ Under $900
Asus Gaming Laptop Intel® i7   | 16GB | FHD |           17.0″ Under $1200
MacBook Gold* Intel® i5   | 8GB | FHD |             12.0″ Under $1200
Alienware AW17R3* Intel® i7   | 16GB | FHD|            17.3″ $Under 2000




Best Laptop to edit Music/Beats | Edit Video's | Edit Movies : 2016-2017












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Thursday, November 24, 2016

Does Masteron (DHT, Drostanolone Propionate) Lower / Decrease Cortisol Levels?

:::Q:::
"Area, does Masteron have an effect on Cortisol? Does it decrease cortisol levels?"

~Dave Q

:::A:::
Research shows that Dihydrotestosterone inhibits the HPTA stress response by cross-activating estrogen-Receptor beta, this causes a decrease in circulating corticosteroids, strong compounds, like Masteron, tend to have direct blocking action on Cortisol, by acting both at the hypothalamus and by acting on beta-endorphin related pathways [!].

So Yes, Masteron absolutely can lower Cortisol levels. 

Perhaps not as much as more ''official'' cortisol blockers, but it does to an extent.

***SOURCES***

Horm Behav. Author manuscript; available in PMC 2013 Jan 1.
Published in final edited form as:
Horm Behav. 2012 Jan; 61(1): 147–155.
Published online 2011 Oct 1. doi:  10.1016/j.yhbeh.2011.09.010
PMCID: PMC3264812
NIHMSID: NIHMS334274


J Neurosci. 2006 Feb 1;26(5):1448-56.

Masteron VS Andractim for Estrogen Control & Gynecomastia.



During a steroid cycle, Estrogen control is crucial to both minimizing suppression, maintaining gains, ensuring solid, lean gains, and eliminating the risk of water retention and gyno - or male breast growth. 

The question, is whether Masteron or Andractim compare better in terms of reducing current incidence of ''gyno'' and performing the estrogen control duties that a DHT-compound can play.
Out of those options, evidence is most important, and strongly on the side of Andractim for 'local estrogen control'. Andractim favours the treatment of gynecomastia (male breast growth) better than Masteron (drostanolone propionate/enanthate) does. However, Masteron ranks better at hardening gains and increasing fat loss/water loss. Masteron also appears to have a stronger effect on libido.


Masteron ranks a bit better in increasing strength, while Andractim seems to produce quicker effects on gyno reduction.

If you were to compare the two, the factors you would look at are...


  • Are you looking for a Gynecomastia solution primarily?
  • Are you looking to cut serious water, and are you also stacking Deca (Nandrolone) with your cycle?
  • Are you looking for strength increases?
If you answered "Yes" to the first question then Andractim is the way to go. If you answered Yes to the other two questions, then Masteron is the one you want. So that's that, ultimately it comes down to what YOUR goals are and your current cycle or regimen, if you aren't using anabolic steroids at all and are just looking for a solution to male breast growth then Andractim is your best friend.


***SOURCES***
The Vital Three



J Clin Endocrinol Metab. 2002 Apr;87(4):1467-72.

 J Urol. 2008 Feb;179(2):684-8. Epub 2007 Dec 20.

J Clin Endocrinol Metab. 2011 Feb; 96(2): 430–437.
Published online 2010 Dec 22. doi:  10.1210/jc.2010-1865

J Clin Endocrinol Metab. 2001 Sep;86(9):4078-88.

Wednesday, November 23, 2016

Can Andractim DHT Gel Be Used to Treat Impotence? A Review of the Research.




Andractim DHT Gel, or Dihydrotestosterone gel, is a hormonal gel for Men often used to treat male breast growth (Gynecomastia) and to reduce the nipple swelling associated with it [1] [2]. The gel comes in a box, with specially designed tubes for dispensing the gel, and remains a top-selling pharmaceutical hormone product available over the Internet [3] [4] [5]

Off-label, Andractim is occasionally used by bodybuilders to reduce water weight, and to decrease the side-effects associated with other anabolic steroids [6] [7]. Andractim is not approved medically for this purpose, but all DHT-based steroidal compounds carry the effect of reducing water retention and decreasing estrogen levels [8] [9].

The most remarkable form of Estrogen (the ''woman's hormone'') in Men, and the one most associated with both cardiovascular health, and hormonal balance is "E2" or Estradiol.

Dihdyrotestosterone-like compounds, including Andractim, are efficient at establishing a balance between Testosterone and Estrogen. They also treat hypogonadism and some symptoms of infertility, including poor sperm quality and low sperm count very efficiently. Andractim gel is one of the most studied, but not necessarily the only option [10] [11].

In regards to Erectile Dysfunction, also known as 'impotence', Dihydrotestosterone gels improve all domains of sexual function, including orgasmic function [!], and rapidly replenish erectile function in aging men and men in whom are previously diagnosed with hypogonadism or a low Testosterone level [12] [13].

Andractim does this job well as it absorbs through the skin, rapidly elevating the levels of the androgen and activating androgenic pathways, which results in beneficial effects on manhood and longevity [14] [15].

Therefore andractim gels and all DHT-like compounds, are highly recommended especially when Testosterone treatment alone fails. 

After all, Dihydrotestosterone is the active androgen in the maintenance of penile nitric-oxide synthase activity; essentially meaning that it establishes and maintains healthy erectile function in Men. Testosterone itself does not perform this role, and therefore DHT (Dihydrotestosterone) is a more effective treatment for male impotence rather than Testosterone.

Lastly, DHT may be useful in treating sexual dysfunction in older Men in whom are currently taking an SSRI-antidepressant, alone or combination with Viagra and / or Yohimbine. {Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers.}

Andractim is only dispensed by All Saints Clinic, any other sites claiming to sell Andractim are likely fake, if they do not lead back to the ASC. Read the article regarding fake andractim gel alerts.


***IMPORTANT SOURCES***






IN/Tags: can dht gel be used to treat impotence, can dihydrotestosterone cure erectile dysfunction, can dihydrotestosterone gel cure ssri sexual dysfunction, andractim gel for pssd, andractim gel for post-ssri sexual dysfunction, dihydrotestosterone gel for improving sexual function in young men, dihydrotestosterone gel for curing impotence, DHT Gel for curing PSSD, DHT Gel cures PSSD!, a review of new evidence includes summaries from GFEALS Co and University of Maryland concludes that...

Friday, November 18, 2016

Herbs that Cause Disinhibition / Fearlessness (Supplements to Induce Fearlessness / Disinhibition)

::::Q::::

"Area, what supplements can I take to make me fearless?"

:::::A:::::
There aren't really any supplements that have been developed specifically to induce fearlessness, but there are supplements that have that effect. 

Some of them, like Kratom, simply blunt emotional capacity and cause one to be able to easier to dissociate themselves. Kratom is also a pain-relief herb that can be smoked, snorted, or injected.  However, ingestion is the most common method of administration. It's also safer to drink Kratom like a tea, or consumed as capsules, than any other way.


Other herbs, like Kava Kava, have a direct fear reducing effect, they block anxiety, and they tend to heighten confidence and cause euphoria.

Kratom and Kava Kava can both be bought at Top Extracts.

  • CLICK HERE to be taken to the site with a VIP code.

Lastly, there are herbs like Magnolia Offinalis extract which have a Xanax-like effect and tend to rapidly reduce anxiety and can cause disinhibition like benzodiazepines.

Genesis Nutrition Magnolia Officinalis is the best brand and under 25$.

***SOURCES*** 
Biology of Fearlessness / Disinhibition
---------------------------------------------------------------------------------------------------------
|KRATOM Sources|



| Kava Kava Extract Sources |




| Magnolia Officinalis Sources |